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Psychiatrist Dr. Ish Major says that coming down off benzodiazepines can have the same withdrawal symptoms as alcohol, including the shakes. He warns that in as little as three days, you can become chemically dependent on a drug like Xanax. Plus, The Doctors warn against mixing benzodiazepines with other substances, sharing that the demise of so many notable people came from combining benzodiazepines and alcohol.