The Doctors’ 2,500-Pound Weight Loss Special

When Desiree was 19, she tore the ligaments in her knees in a workplace accident. At about the same time, her father was diagnosed with cancer. The 34-year-old makeup artist says the two traumatic events led her to soothe her stress and anxiety with...

Mike, 26, says he was always a big kid, even bigger than his kindergarten teacher. As an adult, he filled up on 10,000 calories in an average day, which caused his weight to swell to 607 pounds. Hear how Mike dealt with an exercise setback. And, get...

Amy and Matthew say they had grown too comfortable together. Weighing in at a combined 822 pounds, the couple indulged in huge portions and fast-food meals. After a dramatic weight loss transformation, the couple shares a special surprise!

At 375 pounds, Jeramy says he only took pictures from the chest up, and dressed in clothes that made him feel like he looked smaller. Whenever he was worried about something, the high school teacher says he would turn to food for comfort. Learn why a...

When Desiree was 19, she tore the ligaments in her knees in a workplace accident. At about the same time, her father was diagnosed with cancer. The 34-year-old makeup artist says the two traumatic events led her to soothe her stress and anxiety with...