Hi, Brianna, I'm glad that your vitamin A is ok. About your post on
gabapentin/neuronitn and my note about its effect on lowering vitamin D
in the body, my original information comes from journal articles. I
spent some time reviewing many of the latest journal articles on this
subject. I found a review of a large number of studies. In the review,
it is stated that some antieleptic drugs (AED's) are "enzyme inducing"
and others are "non-enzyme inducing," specifically the P-450 molecule,
which is a liver enzyme that is commonly known to metabolize drugs.
P-450 has been shown to catabolize vitamin D. While gabapentin has not
been found to be enzyme inducing, it has so far been found to cause
significant bone loss at the hip and lower spine. But, there has been
no study specifically designed to study gabapentin and bone metabolism,
that is, there's not enough information about why bone loss occurs
frequently with gapapentin. It is only known that the mechanism is not
related to the P-450 enzyme. My guess is that there is another
mechanism affecting the vitamin D pathway caused by gabapentin, and I
will keep on the lookout for studies on this. Thanks for bringing up
this issue. I will take gabapentin off my list and replace it with
"anti-seizure drugs" with a note that not all drugs have been
specifically tested for their effects on bone metabolism and the link
between enzyme inducing AED's, non-enzyme inducing AED's, and vitamin D
catabolism. The review article mentioned above is:
"Bone and calcium metabolism and antiepileptic drugs" Alberto Verrottia, Giangennaro Coppola, Pasquale Parisi, Angelika Mohn, Francesco Chiarelli Clinical Neurology and Neurosurgery 112 (2010) 1–10
Hey Brianna, out of curiosity what are some of the side effects you experience with Forteo? I know everyone is different but I was just wondering in general. Thanks,
Bri, it has been a while since we have heard from you. Is there anything new to report? Are you healing? I hope you ae doing well and that you have a beautiful, fun filled Christmas. Post a blog letting us know. I am assuming you are done for the semester so now you can concentrate for the next few weeks on taking care of your health. i hope all is well. Best of luck, Bobbie
User Comments - stkatesgirl
Hi there
Thank you
I already have it... I take fosamax every week..And I take Vitamin D and Calcuium every ..
Yes I know The Danger...but there is nothing else that treats Polymyalgia Rheumatica ..
Peace
Cherie.
Hey :) Do you take Advair? I just heard on TV is can cause osteoporosis. Not sure if other inhalers do the same thing. Hope things are going ok.
Melissa.
Hi, Brianna, I'm glad that your vitamin A is ok. About your post on gabapentin/neuronitn and my note about its effect on lowering vitamin D in the body, my original information comes from journal articles. I spent some time reviewing many of the latest journal articles on this subject. I found a review of a large number of studies. In the review, it is stated that some antieleptic drugs (AED's) are "enzyme inducing" and others are "non-enzyme inducing," specifically the P-450 molecule, which is a liver enzyme that is commonly known to metabolize drugs. P-450 has been shown to catabolize vitamin D. While gabapentin has not been found to be enzyme inducing, it has so far been found to cause significant bone loss at the hip and lower spine. But, there has been no study specifically designed to study gabapentin and bone metabolism, that is, there's not enough information about why bone loss occurs frequently with gapapentin. It is only known that the mechanism is not related to the P-450 enzyme. My guess is that there is another mechanism affecting the vitamin D pathway caused by gabapentin, and I will keep on the lookout for studies on this. Thanks for bringing up this issue. I will take gabapentin off my list and replace it with "anti-seizure drugs" with a note that not all drugs have been specifically tested for their effects on bone metabolism and the link between enzyme inducing AED's, non-enzyme inducing AED's, and vitamin D catabolism. The review article mentioned above is:
"Bone and calcium metabolism and antiepileptic drugs"
Alberto Verrottia, Giangennaro Coppola, Pasquale Parisi, Angelika Mohn, Francesco Chiarelli
Clinical Neurology and Neurosurgery 112 (2010) 1–10
Thanks for the info! I appreciate it!
Melissa.
Hey Brianna, out of curiosity what are some of the side effects you experience with Forteo? I know everyone is different but I was just wondering in general. Thanks,
Melissa.
How are you feeling? Has your wound healed and you are off antibiotics?
Melissa.
How were your holidays? I hope you are starting to feel better and heal well. Have a Happy New Year!
Melissa.
Bri, it has been a while since we have heard from you. Is there anything new to report? Are you healing? I hope you ae doing well and that you have a beautiful, fun filled Christmas. Post a blog letting us know. I am assuming you are done for the semester so now you can concentrate for the next few weeks on taking care of your health. i hope all is well. Best of luck, Bobbie
How are you doing?
Melissa.
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