Here is a link to the latest journal article released by the European Journal of Clinical Nutrition: http://www.ncbi.nlm.nih.gov/sites/entrez. Publicly-available information is below:
Vitamin D and calcium insufficiency-related chronic diseases: molecular and cellular pathophysiology
M Peterlik and H S Cross
Eur J Clin Nutr 2009 63: 1377-1386; advance online publication, September 2, 2009; 10.1038/ejcn.2009.105
Absract: A compromised vitamin D status, characterized by low 25-hydroxyvitamin
D (25-(OH)D) serum levels, and a nutritional calcium deficit are widely
encountered in European and North American countries, independent of
age or gender. Both conditions are linked to the pathogenesis of many
degenerative, malignant, inflammatory and metabolic diseases. Studies
on tissue-specific expression and activity of vitamin D metabolizing
enzymes, 25-(OH)D-1
-hydroxylase
and 25-(OH)D-24-hydroxylase, and of the extracellular calcium-sensing
receptor (CaR) have led to the understanding of how, in non-renal
tissues and cellular systems, locally produced 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) and extracellular Ca2+ act jointly as key regulators of cellular proliferation,
differentiation and function. Impairment of cooperative signalling from
the 1,25-(OH)2D3-activated vitamin D receptor
(VDR) and from the CaR in vitamin D and calcium insufficiency causes
cellular dysfunction in many organs and biological systems, and,
therefore, increases the risk of diseases, particularly of
osteoporosis, colorectal and breast cancer, inflammatory bowel disease,
insulin-dependent diabetes mellitus type I, metabolic syndrome,
diabetes mellitus type II, hypertension and cardiovascular disease. Understanding the underlying molecular and cellular processes provides
a rationale for advocating adequate intake of vitamin D and calcium in
all populations, thereby preventing many chronic diseases worldwide.
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Thank you for posting this. I recently was diagnosed with Vita D deficiency. Currently taking 50,000 units (I.U.) per week and getting ready to move over to 1x per month dose. Was pretty scary what I was going through as far as symptoms and I am only 32. HOW can it be pushed that during a CBC to make it mandatory to pull a FULL VITAMIN scan along with it? I think SOOOO many diseases can be prevented by simply finding out if there is a vitamin deficiency. I just cannot even imagine what it would have been like if it hadn't of been found as quickly as it was. I suffered for years silently but had enough over the last few months and finally found the issue. I think I was lucky that I had a good doc to find it immediately.
Please add the following symptoms to your vitamin d deficiency list:
Hot/cold flashes
Nausea
Severe Fatigue
Women: Irregular Menstrual cycles
Sweats
Weight Loss/Gain
Loss of Appetite
Vision changes
temperature changes
hot/cold zones on skin
dry skin/oily
unexplained acne (past a normal hormonal age)
Hi, Midnitesun, thanks for your message. I'm really glad that your doctor figured this out when you are still so young. Yes, I will gladly add your list to my list of deficiency symptoms on my profile. Question: is your doctor testing you periodically so make sure that your level hasn't dropped again? If not, get it done immediately. A friend was severely deficient with a level of 5 ng/ml. She was put on the 50K pill. After her level got to 32 ng/ml after 6 weeks, her doctor dropped her down to 1,000 IU's per day. In 4 months on 1,000 IU's, her level dropped to 22 ng/ml. She got a new doctor who put her back on the 50K pill and has recommended that she get her level to 60-100 ng/ml. We're waiting for her latest results this week. If you were deficient and put on the 50K pill, and now you are only on ~1,600 IU's per day (50K 1x/mo), your level has most likely dropped as my friend's did. Ask your doctor to keep re-checking your level every 3-6 months till you know what level of vitamin D keeps your level healthy. I would shoot for 60-100 ng/ml as my friend's doctor has recommended. I am keepin my level at 80-100 ng/ml for life.
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